GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1411478 | 1 | rs4652547 | chr1:180954089 | MR1 | chr1:181003139-181024633:+ | -0.13 | -3.54 | 0.000438 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs4652547 | chr1:180954089 | STX6 | chr1:180913175-180992046:- | -0.2 | -4.11 | 4.69E-5 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs4652548 | chr1:180954130 | MR1 | chr1:181003139-181024633:+ | -0.13 | -3.54 | 0.000438 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs4652548 | chr1:180954130 | STX6 | chr1:180913175-180992046:- | -0.2 | -4.11 | 4.69E-5 | Progressive supranuclear palsy |
| THCA | cis | rs2243480 | 1 | rs465359 | chr7:65558164 | CCT6P1 | chr7:65216092-65228661:+ | 0.41 | 6.67 | 7.2E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs465359 | chr7:65558164 | CRCP | chr7:65579805-65619551:+ | -0.3 | -4.8 | 2.11E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs465359 | chr7:65558164 | LOC493754 | chr7:65993446-66057363:- | 0.3 | 3.6 | 0.000358 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs465359 | chr7:65558164 | RABGEF1 | chr7:66093890-66276446:+ | 0.52 | 6.65 | 8.06E-11 | Diabetic kidney disease |
| THCA | cis | rs10916814 | 1 | rs4654863 | chr1:20902244 | CDA | chr1:20915444-20945398:+ | -0.23 | -4.7 | 3.46E-6 | Age-related hearing impairment (interaction) |
| THCA | cis | rs10916814 | 1 | rs4654863 | chr1:20902244 | FAM43B | chr1:20878932-20881512:+ | 0.2 | 3.83 | 0.000148 | Age-related hearing impairment (interaction) |
| THCA | cis | rs2295359 | 1 | rs4655684 | chr1:67611772 | WDR78 | chr1:67278574-67390570:- | 0.13 | 3.37 | 0.000814 | Psoriasis |
| THCA | cis | rs4656958 | 1 | rs4656958 | chr1:160856964 | ITLN1 | chr1:160846332-160854960:- | 0.29 | 4.7 | 3.48E-6 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs7535475 | 1 | rs4657039 | chr1:161462728 | FCGR2C | chr1:161551129-161570031:+ | -0.11 | -4.17 | 3.68E-5 | Functional impairment in major depressive disorder, bipolar disorder and schizophrenia |
| THCA | cis | rs8135828 | 1 | rs465742 | chr22:29959335 | NIPSNAP1 | chr22:29950800-29977144:- | -0.27 | -3.7 | 0.000239 | Lipid traits |
| THCA | cis | rs4074493 | 1 | rs4658875 | chr1:231168994 | EXOC8 | chr1:231468483-231473578:- | -0.16 | -3.76 | 0.000191 | Carotid plaque burden (smoking interaction) |